The effect of diclofenac on tendon healing : An experimental study in guinea pigs

Abstract EN

Methods : Sixty four guinea pigs were randomly divided into two main groups (group A: histological study, group B: biomechanical study).

Then tenotomy and repair of right Achilles tendon were done.

Half of the animals in each group received diclofenac (1 mg / kg / bid) and the other half received placebo.

Half of the animals in each group were sacrificed at 2 weeks and the remaining animals at 6 weeks post-operation.

In group A, histological study for determining maturity of healing of tendons in diclofenac and control groups was done, and in group B, tensile force to failure of tendons at two and six weeks of post tenotomy was determined.