Differentiation of fanconi and aplastic anemia using chromosomal breakage test in southern Iran

Abstract EN

Background : Franconia Anemia (FA) is a chromosomal breakage disorder characterized by familial aplastic anemia (AA), various congenital anomalies, and a characteristic chromosomal response to lactogenic stress.

Methods : in this study, a chromosome breakage teat was performed for 38 patients suspected of having FA and age-matched controls.

Results: According to the results, ten patients were considered as FA cases and 15 patients with no chromosomal breaks were considered as AA.

Conclusion : differentiation of FA from AA is very important because the primary treatment is different.

This test should be done in every primary presentation of AA.