Qsar studies on indole substituted potent human histamine H4antagonists : role of physicochemical and statistical parameters

Abstract EN

Quantitative structure activity relationship (QSAR) studies have been made on the compounds of Insole acting as potent human Histamine H4 antagonists.

Statistical techniques were applied to identify the structural and physicochemical requirements for H4 binding affinity.

The activity was doe unmanly controlled by steric and hydrophobic factor with inclusion of different indicator parameters such.

1, I2 and 1 at different positions.

We have undergone a cross validation methodology for deciding predictive power of the QSAR models.