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Expression of Ki-67, C-erbB2 and EGFR in TCC of the urinary bladder and their correlation with tumor grading
Joint Authors
Hosseinzadeh, M.
Mihrabani, D.
Shamsdin, S. A.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 10, Issue 2 (30 Apr. 2008), pp.95-99, 5 p.
Publisher
Publication Date
2008-04-30
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : transitional cell carcinoma (TCC) of the bladder is the most common malignancy of the urinary tract.
Staging and grading of TCC of the bladder and its biomarkers can be indicators of the prognosis.
This study was performed to evaluate the expression of Ki-6, EGFR and c-erbB2 in bladder TCC and their correlation with the tumor grading using immunohistochemistry method.
Methods : Immunohistochemical staining of paraffin blocks of 60 cases of primary TCC was performed and the results were correlated with grading of the tumor on H & E staining.
Results : the expression of EGFR was significantly higher than c-erbB2 and Ki-67 in TCC of the bladder (p < 0.05).
This increase was higher in 3 and 4 grades for EGFR and c-erbB2 when compared with EGFR and Ki ز(p<0.05) 67 Conclusion : expression of EGFR and c-erbB2 is useful in the prognosis of grading and tumor aggressiveness.
American Psychological Association (APA)
Shamsdin, S. A.& Mihrabani, D.& Hosseinzadeh, M.. 2008. Expression of Ki-67, C-erbB2 and EGFR in TCC of the urinary bladder and their correlation with tumor grading. Iranian Red Crescent Medical Journal،Vol. 10, no. 2, pp.95-99.
https://search.emarefa.net/detail/BIM-28243
Modern Language Association (MLA)
Shamsdin, S. A.…[et al.]. Expression of Ki-67, C-erbB2 and EGFR in TCC of the urinary bladder and their correlation with tumor grading. Iranian Red Crescent Medical Journal Vol. 10, no. 2 (Apr. 2008), pp.95-99.
https://search.emarefa.net/detail/BIM-28243
American Medical Association (AMA)
Shamsdin, S. A.& Mihrabani, D.& Hosseinzadeh, M.. Expression of Ki-67, C-erbB2 and EGFR in TCC of the urinary bladder and their correlation with tumor grading. Iranian Red Crescent Medical Journal. 2008. Vol. 10, no. 2, pp.95-99.
https://search.emarefa.net/detail/BIM-28243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 98-99
Record ID
BIM-28243