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In vitro antidermatophytic activity of diospyros crassiflora hiern (ebenaceace)
Joint Authors
Etoa, F. X.
Dzoyem, JP.
Tangmouo, JG.
Kechia, FA.
Lontsi, D.
Lohoue, PJ.
Source
Sudanese Journal of Dermatology
Issue
Vol. 4, Issue 1 (30 Apr. 2006), pp.10-15, 6 p.
Publisher
Sudanese Association of Dermatologists
Publication Date
2006-04-30
Country of Publication
Sudan
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background Dermatophytoses constitute an important public health problem as yet unresolved.
In most African countries, traditional phytomedicine is used to make faces at this disease.
Plants from the genus Diospyros are known for their various biological activities, but Diospyros crassiflora has not been previously performed for antidermatophytic activity.
Objectives to study the In vitro antidermatophytic activity of extract from the stem bark of Diospyros crassiflora and to isolate the active compound responsible for the activity observed.
Methods Clinical isolates of dermatophytes (Trichophyton rubrum, Trichophyton soudanense, Microsporum canis, Microsporum langeronii, Microsporum gypseum) were tested in vitro by cup-plate agar diffusion and broth macrodilution methods.
Results the growth of all dermatophytes tested was inhibited by the extract and plumbagin.
The diameter of inhibition zones varied from 9-13 mm and from 10-18 mm for the extract and plumbagin respectively.
MIC’s (Minimal inhibitory concentration) values ranged from 6.25-12.5 mg / ml for the extract and 3.12-6.25 μg / ml for plumbagin.
Extract showed fungicidal effect at a concentration of 12.5 mg / ml on T.
rubrum.
Plumbagin was fungicidal on all dermatophytes tested at 12.5 μg / ml excepted T.
rubrum (6.25 μg / ml).
Conclusion Extract from the stem bark of Diospyros crassiflora possess tremendous antidermatophytic activity, the active principle responsible for the activity is a naphtoquinone plumbagin.
Compared to ketoconazole used as standard antifungal the compound isolate could be considered as a promising antidermatophytic agent.
American Psychological Association (APA)
Dzoyem, JP.& Tangmouo, JG.& Kechia, FA.& Lontsi, D.& Etoa, F. X.& Lohoue, PJ.. 2006. In vitro antidermatophytic activity of diospyros crassiflora hiern (ebenaceace). Sudanese Journal of Dermatology،Vol. 4, no. 1, pp.10-15.
https://search.emarefa.net/detail/BIM-282638
Modern Language Association (MLA)
Dzoyem, JP.…[et al.]. In vitro antidermatophytic activity of diospyros crassiflora hiern (ebenaceace). Sudanese Journal of Dermatology Vol. 4, no. 1 (Apr. 2006), pp.10-15.
https://search.emarefa.net/detail/BIM-282638
American Medical Association (AMA)
Dzoyem, JP.& Tangmouo, JG.& Kechia, FA.& Lontsi, D.& Etoa, F. X.& Lohoue, PJ.. In vitro antidermatophytic activity of diospyros crassiflora hiern (ebenaceace). Sudanese Journal of Dermatology. 2006. Vol. 4, no. 1, pp.10-15.
https://search.emarefa.net/detail/BIM-282638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 14-15
Record ID
BIM-282638