Optimizing the use of her-2neu targeting agents in breast cancer : a developing nation perspective
Joint Authors
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 19, Issue 4 (31 Dec. 2007), pp.225-230, 6 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2007-12-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : Her-2 / neu positive breast cancer is an aggressive disease with a higher potential of invasion and metastasis.
It constitutes around 20% of all breast cancer cases and even a higher incidence has been reported in Egypt.
Agents targeting Her-2 have been shown to be associated with improvement in response rate, disease free and overall survival.
Diagnosis : Different biomarkers have recently emerged to predict the benefit of trastuzumab and / or lapatinib.
Phosphatase and tensin homolog (PTEN), topoisomerase 2 alpha (TOPO2A) and p95HER2 have been associated with appealing results in selecting patients who may or may not respond to these agents.
Results and Conclusion : Despite the impressive results of Her-2 / neu targeting agents in both the adjuvant and metastatic phases, still a significant fraction of patients are not offered these agents particularly those in countries with limited resources due to their high cost.
In this review, we will discuss how we can optimally use these agents from a developing nation perspective.
We will elaborate on different schedules available and will highlight the importance of incorporating different biomarkers to assist in proper selection of patients who can optimally benefit these agents.
American Psychological Association (APA)
Azim, Hamdi A.& Azim, Hatim A.. 2007. Optimizing the use of her-2neu targeting agents in breast cancer : a developing nation perspective. Journal of the Egyptian National Cancer Institute،Vol. 19, no. 4, pp.225-230.
https://search.emarefa.net/detail/BIM-282864
Modern Language Association (MLA)
Azim, Hamdi A.& Azim, Hatim A.. Optimizing the use of her-2neu targeting agents in breast cancer : a developing nation perspective. Journal of the Egyptian National Cancer Institute Vol. 19, no. 4 (Dec. 2007), pp.225-230.
https://search.emarefa.net/detail/BIM-282864
American Medical Association (AMA)
Azim, Hamdi A.& Azim, Hatim A.. Optimizing the use of her-2neu targeting agents in breast cancer : a developing nation perspective. Journal of the Egyptian National Cancer Institute. 2007. Vol. 19, no. 4, pp.225-230.
https://search.emarefa.net/detail/BIM-282864
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 229-230
Record ID
BIM-282864