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Evaluation of MIB-1 and p53 overexpression as risk factors in large cell non-hodgkin lymphoma in adults
Joint Authors
al-Bolkainy, Tariq M. N.
Jawdah, Hibah M.
Khalid, Husayn M.
al-Bolkainy, Muhammad N.
Isa, Sad S.
al-Hattab, Umar H.
Mukhtar, Nadiyah M.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 19, Issue 4 (31 Dec. 2007), pp.231-238, 8 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2007-12-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background : Improvement of current results of ther-apy for large cell non-Hodgkin lymphoma patients can be achieved by optimization of initial treatment or application of risk-adapted therapy.
The international prognostic index (IPI), introduced to identify high-risk patients, was recently criticized because it was based on clinical risk factors only, ignoring important tumor molecular risk factors and it fails to identify a sector of high-risk patients, who ultimately relapse.
Objective : The aim of this study is to evaluate the value of two tumor biomarkers : MIB-1 and p53 as potential risk factors in diffuse large cell lymphoma.
MIB-1 measures tumor cell proliferation, whereas p53 is related to tumor progression and response to chemotherapy.
Patients and Methods : The study was done on 69 adult patients with diffuse large cell NHL (58 B-phenotype and 11 T-phenotype).
Clinical risk assessment was determined by the IPI and patients with a score of 3 or more were considered high-risk.
Expression of MIB-1 and p53 was determined by immunohistochemistry and nuclear staining was quantities by image analysis.
Immunoexpression was considered high for MIB-1 nuclear count ≥50%and p53 counts≥ 20%.
Evaluation included both response to chemotherapy (mostly CHOP), as well as 2-year overall survival analysis.
Results : The IPI was the only clinical variable which had a significant impact on survival.
Over expression of both MIB-1 and p53 was associated with poor response to treatment, as well as unfavorable survival.
Combined risk factor analysis revealed that only MIB-1 was an independent variable.
MIB-1 could also identify some high-risk patients previously categorized in the IPI lowrisk group.
Conclusions : MIB-1 is an independent biologic risk factor for large cell NHL.
In order to optimize risk assessment of these patients, it is recommended to construct a new prognostic index by adding MIB-1 overexpression to the other clinical factors of standard IPI.
This may allow better identification of high-risk patients and help to guide planning of effective initial treatment.
American Psychological Association (APA)
al-Bolkainy, Tariq M. N.& al-Bolkainy, Muhammad N.& Khalid, Husayn M.& Mukhtar, Nadiyah M.& Isa, Sad S.& Jawdah, Hibah M.…[et al.]. 2007. Evaluation of MIB-1 and p53 overexpression as risk factors in large cell non-hodgkin lymphoma in adults. Journal of the Egyptian National Cancer Institute،Vol. 19, no. 4, pp.231-238.
https://search.emarefa.net/detail/BIM-282873
Modern Language Association (MLA)
al-Bolkainy, Tariq M. N.…[et al.]. Evaluation of MIB-1 and p53 overexpression as risk factors in large cell non-hodgkin lymphoma in adults. Journal of the Egyptian National Cancer Institute Vol. 19, no. 4 (Dec. 2007), pp.231-238.
https://search.emarefa.net/detail/BIM-282873
American Medical Association (AMA)
al-Bolkainy, Tariq M. N.& al-Bolkainy, Muhammad N.& Khalid, Husayn M.& Mukhtar, Nadiyah M.& Isa, Sad S.& Jawdah, Hibah M.…[et al.]. Evaluation of MIB-1 and p53 overexpression as risk factors in large cell non-hodgkin lymphoma in adults. Journal of the Egyptian National Cancer Institute. 2007. Vol. 19, no. 4, pp.231-238.
https://search.emarefa.net/detail/BIM-282873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 236-238
Record ID
BIM-282873