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Effect of chromium- picolinat on biochemical and histopathological altrations in rats
Joint Authors
Ghanim, Hala. M
Darwish, Nifin.S
Mahmud, Amani Abd al-Ghaffar
Source
The Egyptian Journal of Biochemistry and Molecular Biology
Issue
Vol. 27, Issue 1 (30 Jun. 2009), pp.163-176, 14 p.
Publisher
Egyptian Society of Biochemistry and Molecular Biology
Publication Date
2009-06-30
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Topics
Abstract EN
Chromium III tris (pollinate) [Cr (pic) 3] is a popular nutritional Supplement ; however its safety has been questioned, especially with regard to its ability to act as a clastogen.
The aim of the present work was to evaluate the biochemical and morphological changes in the liver following oral administration of Cr-pollinate and the possible protective effect of ascorbic acid (vitamin C) in rats.
Fifty male Sprague Dawly rats were divided into five groups included the control group, the rest four groups treated orally with picolinte (0.8 and 1.5 mg / 100 g b.
w) alone or in combination with Vitamin C (0.5 mg / 100 g b.
w) for 8 weeks.
The results indicated that animals treated with Crpicolinate alone at the high dose level (1.5 mg / 100 g b.
w) showed a significant decrease in reduced glutathione (GSH) level and activity of glutathione peroxidase (GPx) in liver homogenate or blood accompanied with a significant increase in serum sFas ; 8-hydroxy-2–deoxyguanosine and malondialdehyde (MDA) levels.
The hepatocytes showed some degenerative changes in the form of swollen cells and degenerating nuclei, yet some cells showed regeneration by division of their nuclei The methyl green pyronin (MGP) stain showed less level of DNA in the nuclei, the cells appeared swollen and fused in some areas.
It could be concluded that consumption of Cr-pollinate for a long time is contributing to health hazards and induced several hazards to liver.
Supplementation with extra amounts of vitamin C may be useful to restrain the chromium-induced biochemical and morphological changes to the liver.
It is believed that oxidative stress due to Cr-pollinate is a factor contributing to this health hazards
American Psychological Association (APA)
Mahmud, Amani Abd al-Ghaffar& Ghanim, Hala. M& Darwish, Nifin.S. 2009. Effect of chromium- picolinat on biochemical and histopathological altrations in rats. The Egyptian Journal of Biochemistry and Molecular Biology،Vol. 27, no. 1, pp.163-176.
https://search.emarefa.net/detail/BIM-28301
Modern Language Association (MLA)
Mahmud, Amani Abd al-Ghaffar…[et al.]. Effect of chromium- picolinat on biochemical and histopathological altrations in rats. The Egyptian Journal of Biochemistry and Molecular Biology Vol. 27, no. 1 (Jun. 2009), pp.163-176.
https://search.emarefa.net/detail/BIM-28301
American Medical Association (AMA)
Mahmud, Amani Abd al-Ghaffar& Ghanim, Hala. M& Darwish, Nifin.S. Effect of chromium- picolinat on biochemical and histopathological altrations in rats. The Egyptian Journal of Biochemistry and Molecular Biology. 2009. Vol. 27, no. 1, pp.163-176.
https://search.emarefa.net/detail/BIM-28301
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 174-176
Record ID
BIM-28301