Evaluation of general anaesthesia by using propionylpromazine, xylazine and ketamine in rabbits

Abstract EN

Safe and effective anesthetic regimens have been described for use in rabbits, partially because of the susceptibility of this species to fatal respiratory arrest.

The present study was conducted to evaluate the efficacy of anesthetics, analgesics combinations an anesthesia in twenty five local breed rabbits.

Rabbits were injected intramuscularly by : Propionylpromazine 0.5mg/kg B.W.

as premedication, after 10minutes later Xylazine and Ketamine Hydrochloride at a dose of 20mg/kg, 50mg/kg respectively.

The results of the physiological parameters of the control group at the period of zero time concerning rectal body temperature, respiratory rate, heart rate were 38.00 ± 0.29 ºC; 96.36 ± 3.33bpm ; and 147.20 ± 6.46/minutes respectively.

While in treated group at the periods 10, 20, 35, 50, 65, 80 and 95 minutes were 37.76 ± 0.61 ; 37.34 ± 0.28 ; 37.00 ± 0.29 ; 37.00 ± 0.35 ; 36.92 ± 0.38 ; 35.80 ± 0.40 ; 34.92 ± 0.53 ºC ; 96.36 ± 3.33 ; 41.00 ± 1.37 ; 45.00 ± 2.01 ; 45 ± 2.01 ; 40.00 ± 1.31 ; 40.00 ± 1.31 ; 39.20 ± 1.01 bpm ; and 147.20 ± 6.46 ; 142.00 ± 3.73 ; 145.00 ± 3.26 ; 144.48 ± 3.31 ; 130.00 ± 4.18 ; 140.00 ± 3.49 ; 138.68 ± 2.93 beats / minutes.

The results of biochemical tests : Glucose, ALP, GPT, GOT in control group (zero time) were : (137.40 ± 1.97 mg/dl ; 53.09 ± 2.13 U / L ; 51.48 ± 4.31 U/L ; 116.9 ± 09.82 U / L) respectively.

And in treated group at the periods (10, 20, 35, 50, 65, 95 minutes and 24 hours) respectively were 139.60 ± 0.79 ; 207.60 ± 5.00 ; 222.20 ± 7.42 ; 359.20 ; ± 18.89 ; 341.60 ±15.30 ; 337.7 ± 76.39 and 199.92 ± 9.14 mg/dl ; 39.74 ± 2.74; 42.55 ± 3.29 ; 39.65 ± 4.13 ; 42.48 ± 2.62 ; 56.56 ± 2.16 ; 47.41 ± 3.61 and 42.84 ± 4.16 U/L ; 46.17 ± 3.92 ; 39.34 ± 3.01 ; 44.69 ± 3.05 ; 49.98 ± 3.16 ; 51.65 ± 4.03 ; 47.22 ± 2.54 and 72.63 ± 4.98 U / L, and 94.72 ± 8.24 ; 86.22 ± 5.59 ; 90.82 ± 6.89 ; 76.65 ± 4.12 ; 82.70 ± 4.69 ; 100.6 ± 7.39 and 126.6 ± 7.77 U / L.

The conclusion of this study investigate that the lose of righting reflex was 4.760 ± 0.421 minutes ; induction time was 8.44 ± 1.05, the time to complete muscle relaxation was 3.920 ± 0.321 minutes, surgical time 41.48 ± 2.11 minutes, and recovery time was 45.76 ± 2.43 minutes ; in which the surgical period was enough for the most of surgical interference, while the recovery period was smooth and short in comparison with another anesthetic regimen.