تأثير نبات عنب الذئب Solanum nigrum L. في الإصابة بداء الأكياس العدرية الثانوي في الفئران البيض : نمو و تطور الأكياس العدرية

Abstract EN

Immunomodulating activity of alcoholic extract of the black nightshade Solatium nigrum L.

leaves was tested, in BALB/c mice, against infection with secondary hydatid disease.

Growth and development of cysts in mice treated with this extraot, prior to infection with protoscoleces of sheep and human origin, was investigated, taking into consideration number, weight and diameter of cysts grown, in addition to percentage reduction in number of cysts and their distribution in different organs of the body.

Mice were injected with plant extract at concentrations of 0.1, 0.2, 0.3, 0.4 and 0..5mg/m 1/mouse.

1-5 doses (with 72 hour intervals between successive doses) were injected.

The results obtained show a marked reduction in number, weight and size of the cysts with high percentage reduction and a marked variation in the weight of liver and spleen, and their organ indices, in mice treated with the plant extract, compared to the control group, was also obtained, indicating that the black nightshade possesses an immunomodulating activity against infection with secondary hydatid disease.