Chronic obstructive lung disease and osteoporosis

Abstract EN

Objective : The aim of the work is to study the degree of declining in bone mineral densities (BMD) in Chronic obstructive pulmonary disease COPD patients and the correlations of decrease in BMD to body mass indices (BMI), smoking indices, staging of COPD, and respiratory muscle strengths (RMS).

Methods : This study was performed on fifty three male patients with COPD and 40 male controls.

All patients were subjected to : pulmonary function tests (FVC % of predicted, FEV1 % of predicted, FEV1 / FVC ratio), calculation of body mass index, respiratory muscle strength and Dual Energy X Ray Absorptiometry .(DEXA) Results : There were significant negative correlations between DEXA spine and hip (T score and Z score)) and smoking indices (p=0.020, 0.002, 0.020 and 0.002 respectively) and stages of COPD (p=0.000, 0.001, 0.000 and 0.004 respectively).

There were significant positive correlations between DEXA spine and hip (T score and Z score) and BMI (p=0.001, 0.022, 0.000 and 0.001 respectively).

There were significantly positive correlations between DEXA spine and hip (T score and Z score) and RMS (p=0.000, 0.000, 0.003 and 0.003 respectively).

COPD patients without and with steroid treatment had 4.29 and 9.69 greater probability of low BMD than control.

About 75.5 % of COPD patients had low BMD (26.4 % for osteopenia and 49.1 % for osteoporosis).

Conclusions : Low BMD was found in 75.5 % of COPD patients.

Low BMD in COPD patients were associated with : higher smoking indices, higher stages of COPD, lower BMI, lower RMS and steroid use, so COPD patients with theses risk factors must be screened with DEXA.