Synthesis and characterization of new schiffs bases derived from d-erythroascorbic acid and pyrimidines

Abstract EN

The new C-5 Schiff bases derived from D-erythroascorbic acid containing pyramiding unit were synthesized by condensation of D-erythroascorbic acid with aromatic amine (containing pyramiding unit)in dry benzene using glacial acetic acid as a catalyst.

D-erythroascorbic acid was synthesized by four steps (Scheme 1), while the aromatic amine which is containing oxopyrimidine or thiopyrimidine synthesized by the reaction of chalcone urea or thiourea in acid or basic medium, respectively .

The structure of synthesized compounds have been characterized by their melting points, FTIR , UV-Vis and 1 HNMR spectroscopy .

All the synthesized compounds have been screened for their antibacterial activities.

They exhibited good antibacterial activity against Escherichia coli (G-) and Staphylococcus aureus (G+), while the compounds [V]b , [VI]b and [VII]b did not show any biological activity against this type of bacteria.