Role of apoptosis proteins survivin, bax and BCL-XL in laryngeal squamous cell carcinoma progression
Other Title(s)
دور بروتينات موت الخلية المبرمج (السيرفيفين، الباكس البي-سي-ال-اكس ال) في تطور سرطان الحنجرة
Joint Authors
Muhammad, Walid Abd al-Hafiz
Muhammad, Iman Salah
al-Rifai, Abir Muhammad
Source
Issue
Vol. 32, Issue 3 (30 Sep. 2008), pp.93-100, 8 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2008-09-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract AR
يلعب السيرفيفين دورا هاما في ابتداء سرطان الحنجرة و تطوره لمراحل متقدمة.
عاملا (الباكس و البي - سي إل - إكس إل) يؤثران في ابتداء سرطان الحنجرة, و لكنهما بدون تأثير على تطور السرطان لمراحله المتقدمة, انتشاره الموضعي, أو امتداده للغدد الليمفاوية.
Abstract EN
Aims: we used immunohistochemistry to investigate a potential role of SVV as an early predictor of malignant transformation in precancerous and cancerous lesions of the larynx, we also sought to examine the expression of Bcl-XL and Bax in laryngeal SCC, analyze the relationships between their expression and prognostic factors including site, histological grade, clinical staging and lymph node metastasis. Methods & Results: This study included 6 normal laryngeal mucosae, 7 dysplastic laryngeal epithelia, 5 in situ laryngeal carcinomas, and 32 biopsied laryngeal SCC.
Clinical evaluation was done.
Specimens were formalin-fixed, paraffin-embedded, stained with H&E, classified and graded according to WHO classification, (2005) and immunostained to detect Survivin and Bcl-XL and Bax proteins using the avidin-biotin peroxidase method.
Survivin expression gradually increased significantly with advance of laryngeal carcinoma through the sequence of dysplasia, in situ carcinoma and infiltrating carcinoma (P<0.04).
There is a statistically significant increase in Survivin expression with increasing tumor grade (P<0.03) and with advance in clinical staging (P<0.01).
Regarding lymph node metastasis SVV was more expressed in laryngeal SCC exhibiting lymph node metastasis (P<0.02).
Bax expression was decreased significantly in infiltrating laryngeal carcinoma (P< 0.04) compared with pre-malignant lesions of the larynx.
In contrast, Bcl-XL was increased significantly with the advance of laryngeal carcinoma through dysplasia, carcinoma sequence (P< 0.02).
There was no statistically significant difference in either Bax or Bcl-XL expression considering tumor differentiation, advanced clinical staging or lymph node metastasis.
Conclusion: Survivin plays an important role in the initiation of laryngeal cancer and its progression towards higher grades, invasion and metastasis.
Bax and Bcl-XL play their role early in cancer initiation but have nothing to do as the tumor progresses to higher grades, infiltrates deeply, or giving lymph node metastasis.
American Psychological Association (APA)
Muhammad, Walid Abd al-Hafiz& Muhammad, Iman Salah& al-Rifai, Abir Muhammad. 2008. Role of apoptosis proteins survivin, bax and BCL-XL in laryngeal squamous cell carcinoma progression. Assiut Medical Journal،Vol. 32, no. 3, pp.93-100.
https://search.emarefa.net/detail/BIM-28720
Modern Language Association (MLA)
Muhammad, Walid Abd al-Hafiz…[et al.]. Role of apoptosis proteins survivin, bax and BCL-XL in laryngeal squamous cell carcinoma progression. Assiut Medical Journal Vol. 32, no. 3 (Sep. 2008), pp.93-100.
https://search.emarefa.net/detail/BIM-28720
American Medical Association (AMA)
Muhammad, Walid Abd al-Hafiz& Muhammad, Iman Salah& al-Rifai, Abir Muhammad. Role of apoptosis proteins survivin, bax and BCL-XL in laryngeal squamous cell carcinoma progression. Assiut Medical Journal. 2008. Vol. 32, no. 3, pp.93-100.
https://search.emarefa.net/detail/BIM-28720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 99-100
Record ID
BIM-28720