Antimicrobial activity of piperine purified from piper nigrum

Abstract EN

An alkaloid piperine was extracted from dry seeds of plant Piper nigrum with ethanol by using saxohlet extraction then isolation and purification by re- crystallization , the structure of Piperine was confirmed by the IR spectroscopy.

Antimicrobial activity of Piperine was studied against gram+ve, gram-ve bacteria and Candida albicans piperine showed potent antimicrobial activity against tested organisms especially C.

albicans followed by E.

coli and less than on P.

aeruginosa the zone of inhibition ranges from 8 - 23 mm and the minimum inhibitory concentrations ( MIC ) 3.125 - 100mg/ml.