Vaginal misopristol for second trimester termination of pregnancy in scarred uterus

Abstract EN

Objective –To evaluate the safety of vaginal misopristol for second trimester termination of pregnancy in women with scarred uterus.

Method- prospective observational study over one year period , women with second-d trimester termination of pregnancy mainly for intrauterine death, 27 cases had the procedure, misopristol introduced vaginally 200 microgram 12-hourly ,7 women who recruited had scarred uteri and 20 had no history of previous surgery .The outcome and the side effects of the two groups were observed.

Results- 1- There was alonger average time taken for termination in the scarred uterus group when compared with the non scarred group..

2-No extra tablets were required for scarred group with an average of 2 tablets 400 microgram in both group.

3-Other side effects such as nausea, vomiting, diarrhea, fever, and pain were not significantly different for both group.

4-There was no major complication during the study including rupture uterus.

Conclusion- Intra-vaginal misopristol is clinically effective and safe for second trimester termination of pregnancy.

The use of misopristol in scarred uterus must be done with caution and a larger trial is required to prove safety.