Study of the synergistic effect of antimicrobial drugs and plant extracts against staphylococccus aureus strains

Abstract EN

Antimicrobial drugs effective for treatment of patients infected with resistant Staphylococcus aureus (RSA) are limited .Thus, it is important and valuable to find compound that potentiate antimicrobial activity of antibiotics on RSA.

So, our study aims to evaluate the synergistic effect between two antibiotics (Ampicillin and Acaflex) and the extracts of Eucalyptus and Thuja plant against RSA.

We examined the anti-bacterial action of two plants (Eucalyptus and Thuja) extracts on plasma coagulation by staphylococcus aureus and the effect of conventional chemotherapy combined with plant extracts below the MIC.

Coagulation was inhibited in plasma containing (10,20,50,70 and 100mg \ L)for both extracts.

The MICs of Ampicillin and Acaflex for S.aureus markedly reduced from(0.25,0.5 and 1mg \ L) of the four resistant strains to 0.06mg \ L in muller hinton agar (MHA)plates with 20mg \ L Eucalyptus extract and 50mg \ L Thuja extract.

The results suggest that T.

catappa and E.

camaldulensis extracts can be used in treating diseases caused by the test organisms.