Evaluation the effect of platelet rich fibrin matrix on bone healing

Abstract EN

Background : this study was carried out to evaluate the histological and radio graphical behavior of newly developed platelet rich fibrin matrix as bone filler for dental socket after tooth extraction.

Materials and methods: Twenty four rabbits were used for extraction of upper central incisors under general anesthesia .The left side was filled with platelet rich fibrin matrix material and the right side was left for normal healing as control group .The two sockets were sutured.

Results : the results were studies histological after 1, 2, 3, 4 weeks postoperatively.

The histological examination was performed under light microscope for the section stained with heamatoxyline and eosin with assessment of histometric analysis including counting of bone cells osteoblast, osteocyte, bone trabecular number, bone trabecular width, bone trabecular separation, cortical width, blood vessel number and bone marrow space volume at the 2nd ,3rd and 4th week periods interval post operatively.

Histological examination showed the acceleration of bone formation and more rapid healing process in the socket filled with PRFM than in the control socket.

Radio graphical examinations showed that the process of ossification of the socket filled with PRFM started after 2 weeks and completely filled with radiopacity after 4weeks.

Conclusion : this study was illustrated that PRFM material was osteoinductive material that enhances of osteogenesis process in the extraction tooth socket in comparison to the normal physiological healing process.

The results show a positive effect of PRFM and it can be suggested for beneficial use in the practice of dentistry.