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Assessment of serum and salivary oxidative stress biomarkers with evaluation of oral health status in a sample of autistic male children
Joint Authors
Rashid, Mayyadah H.
al-Jabburi, Raja H.
Source
Journal of Baghdad College of Dentistry
Issue
Vol. 23, Issue 3 (30 Sep. 2011), pp.56-60, 5 p.
Publisher
University of Baghdad College of Dentistry
Publication Date
2011-09-30
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : Autism is a severe neurodevelopmental disorder, presents in early childhood, characterized by severe impairments in socialization, communication and behavior.
Autism is considered a multi-factorial disorder that is influenced by genetic, environmental, and immunological factors with oxidative stress as a mechanism linking these factors.
Assessment of any oral manifestations; measurement of oxidative stress in saliva has to be discovered, evaluated and measured in autistics to be used as a potential diagnostic aid since saliva is an ultra-filtrate of serum and meet the demand for inexpensive, noninvasive and accessible diagnostic methodology.
Materials and methods : Oral health status : DMFT / dmft and gingival indices as well Serum and salivary Malondialdehyde (MDA) levels, glutathione (GSH), superoxide dismutase (SOD) and uric acid (UA) were estimated for 58 individuals aged (2-13) years, twenty nine of them were autistics and twenty nine were sex and age matched healthy controls.
Results : The results of this study showed that Iraqi autistic children sample was more likely to be caries-free, with significant abnormalities of the oxidative stress biomarkers.
Conclusion : Saliva can be used as adjunctive diagnostic aid for measurement of the oxidative stress in autism.
Serum GSH and uric acid then serum and salivary Malonyldialdehyde followed by salivary glutathione and serum superoxide dismutase are the most powerful predictors of autism spectrum disorder respectively.
American Psychological Association (APA)
Rashid, Mayyadah H.& al-Jabburi, Raja H.. 2011. Assessment of serum and salivary oxidative stress biomarkers with evaluation of oral health status in a sample of autistic male children. Journal of Baghdad College of Dentistry،Vol. 23, no. 3, pp.56-60.
https://search.emarefa.net/detail/BIM-287998
Modern Language Association (MLA)
Rashid, Mayyadah H.& al-Jabburi, Raja H.. Assessment of serum and salivary oxidative stress biomarkers with evaluation of oral health status in a sample of autistic male children. Journal of Baghdad College of Dentistry Vol. 23, no. 3 (2011), pp.56-60.
https://search.emarefa.net/detail/BIM-287998
American Medical Association (AMA)
Rashid, Mayyadah H.& al-Jabburi, Raja H.. Assessment of serum and salivary oxidative stress biomarkers with evaluation of oral health status in a sample of autistic male children. Journal of Baghdad College of Dentistry. 2011. Vol. 23, no. 3, pp.56-60.
https://search.emarefa.net/detail/BIM-287998
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 60
Record ID
BIM-287998