Histological study of the effect of eucalyptol oil vapours on the development of the palate and tooth germ : experimental study on rats

Abstract EN

Background : Eucalyptol is a natural organic compound.

The aim of this study was to evaluate the effect of the eucalyptol oil vapour on the palate and tooth germ development of rats embryos for the periods of (16th day, 18th day intrauterine life and one day old rats) histologically and histomorphometrically.

Materials and Methods : In this study thirty pregnant albino Wistar female rats(2-3 months of age, 200-250 gm of weight( were divided into two groups : Control group not subjected to the synthetic eucalyptol oil inhalation vapour and experimental group subjected to the synthetic eucalyptol oil inhalation vapour.

The embryos at 16, 18 day of intrauterine life and one day old were histologically studied for the development of palate and molar tooth germ development.

Results : The results demonstrated a retardation of the palate and tooth germ development of 16th and 18th intrauterine life embryos of experimental groups in comparison to control.

Immature enamel, wide predentin and interglobular dentin were detected in the tooth germ of embryo (one day old) from pregnant rats exposed to the eucalyptol oil vapour.

Conclusions : Eucalyptol oil vapour can affect on the palate(Failure of fusion of palatine shelves) and tooth germ development (mineralization and maturation process of dentin and enamel respectively showing immature enamel and interglobular dentin with wide predentin).