The study of oral manifestations, oxidative stress marker and antioxidants in serum and saliva of rheumatoid arthritis patients

Abstract EN

Background : Rheumatoid arthritis (RA) is a heterogeneous disease with a spectrum of clinical severity ranging from mild arthritis to a crippling joint disorder with internal organ involvement.

Besides the immunological reaction, there is another biological process, based on the injurious activity of free radicals, playing a major role in the pathogenesis ; an increase in the generation of oxidants and lipid peroxidation products was demonstrated in the serum of RA patients, which correlated with the antioxidant levels.

Subjects, Materials and Methods : Seventy six individuals were enrolled in this study ; Fifty one of them were patients having RA ; twenty five were healthy control individuals matching the patients in age and sex.

Serum and saliva samples have been taken from each subject for biochemical analysis.

Results : The highest number of RA patients was of mild disease activity, while the lowest number was of inactive disease activity.

Xerostomia was the most prominent oral manifestations of RA patients.

The mean of serum and saliva MDA and UA in RA patients was significantly higher than of the healthy controls.

The mean of serum and saliva caeruloplasmin in RA patients was higher than that of the healthy controls.

Conclusion : Rheumatoid arthritis patients were associated with increased oxidative stress, antioxidants and inflammatory markers..

Patients with RA have different oral manifestations xerostomia were the most prominent.

The highest number of RA patients was of mild disease activity.