Lactate dehydrogenase in serum and saliva of ischemic heart disease patients

Abstract EN

Background : lactate dehydrogenase (LDH) is an enzyme detectable in cytoplasm in almost every cell of the human body, which becomes extracellular upon cell death.

Therefore, its extracellular presence is always related to cell necrosis and tissue breakdown.

The aim of this study was to assess LDH in ischemic heart disease patients and chronic periodontitis patients and to assess the role of saliva as a diagnostic tool for this biochemical analysis.

Materials and Methods: One hundred and forty individuals were enrolled in this study; forty of them were patients having ischemic heart diseases (IHD) ; sixty patients were age and sex matched risk groups (thirty patients with hypertension and thirty with diabetes mellitus type 2) ; the last group was age and sex matched apparently healthy control individuals.

Serum and saliva samples have been taken from each subject for LDH analysis.

Periodontal status have been determined using the clinical periodontal sum score (CPSS).

Results : the mean activity of serum LDH was significantly higher in IHD patients compared to healthy controls and risk groups, while salivary LDH was highest in relation to highest score of chronic periodontitis (CPSS).

Conclusions : serum LDH is highly significant in predicting IHD patients, while salivary LDH increases with chronic periodontitis progression.