Control of recurrent oro-labial herpes simplex lesions by in vivo enhancement of salivary peroxidase system

Abstract EN

Background : many studies have been conducted to enhance the salivary innate defense factors against bacteria ; this study was conducted to enhance the salivary natural peroxidase system in vivo to prevent recurrent herpes simplex type 1 infection.

Subjects and methods: This study had been carried out on 40 healthy subjects (mean age 22), who were suffering from recurrent oro-labial lesions.

A mouth rinse was made to stimulate the salivary peroxidase system to produce hypothiocyanite (OSCN-) at an antimicrobial level; the rinse was tried on 30 subjects for 100 days, while the rest were the control.

Results: It had been shown that the use of the rinse led to generation of OSCN- ≥ 100 μM which was highly efficient in reducing recurrent oro-labial herpes simplex lesions in study group.

Conclusion : the properties of a mouth rinse that increases the in vivo generation of salivary OSCN- are : H2O2 3 mM, KSCN 1 mM in PBS pH 5.5, the rinse volume is 5 ml and the time of rinsing is 2 minutes.