The frequency and adequacy of the haemodialysis as important factors in anaemia treatment and response to recombinant human erythropoietin in chronic renal failure

Abstract EN

In this study we have 60 (35 male and 25 female) volunteers patients of CRF due to different causes with anaemia, all the patient on haemodialysis program.

They take Epoetin (Epirax) treatment 50 IU / Kg / dose twice weekly subcutaneously.

The patients are 35 male and 25 female of different body weight (15–to 75 Kg) and different ages ranging from (12 to 68 years).

This study started on 20-10-2010 and end on 10-6-2011 during this time the Hb, PCV, BU, SCr, S-electrolyte (Na+, K+ and Ca+2 ) are taken 2 times / week before the dialysis session, the body wt taken after the dialysis also 2 times / week.

Patient divided into 4 groups (Group 1 :- have 3dialysis session/ week 4 hours duration for each sessionGroup 2 :- 2 dialysis session / week 4 hours for each session, Group 3 :- 3 dialysis session / week 3 hours for each session, Group 4 :- 2 dialysis session / week 3 hours for each session).

In this study we are trying to evaluate the effect of the frequency and adequacy of the dialysis on the responsiveness to the rHUEPO treatment of anaemia in haemodialysis CRF.

Where the inadequate dialysis is another factor of poor response to rHUEPO, although the recent studies showed that moderately increased dialysis adequacy cannot influence morbidity and mortality in HD patients but inadequate dialysis is identified as an important factor of poor response to rHUEPO in HD We conclude :- the group 1 had the better results than the other groups which confirms the idea that not only the efficacy or only the adequacy of the dialysis effect the EPO responsiveness but both of them had a vital role and importance in the EPO responsiveness and thereby in the management of the anemia in CRF on HD program P < 0.0001.