Left ventricular diastolic dysfunction in patients with type-11 diabetes millitus

Abstract EN

Diabetes mellitus is a chronic progressive metabolic disease.

It involves the heart at a relatively early stage even before clinical manifestations become obvious.

The present study was done to assess cardiac functions by echocardiography and Doppler in patients with type-II Diabetes Mellitus before and after control of hyperglycaemia.

This study included 30 patients of uncomplicated diabetes mellitus (duration >1 year) and 30, age and sex matched, healthy subjects.

Pretreatment blood sugar, fasting ( 182,46 + 33.92 mg/dL) and post-prandial ( 245.76 + 37.87 mg/dL ) was significantly higher than the post-treatment values ( 101.93 + 10.17 mg/dL and 152.75 + 15.42 mg/dL respectively).

Systolic functions of LV were within normal range in all patients.

Diastolic dysfunction of LV was very common and was detected in 63% of patients ( E/A < 1.0 ).

None of the control subjects had systolic or diastolic dysfunction.

Diastolic dysfunction persisted even after control of hyperglycaemia.

It is suggested that all patients of DM type-II should be routinely and repeatedly subjected to Echocardiography with Doppler assessment of cardiac functions in long term management of this metabolic disease.

Better glycaemic control may prevent development of diastolic dysfunction, which can lead to heart failure.