Immunohistochemical expressions of matrix metalloproteinase-9 and vimentin in oral squamous cell carcinoma
Joint Authors
Majid, Ahlam H.
Khalil, Afrah A.
Source
Journal of Baghdad College of Dentistry
Issue
Vol. 21, Issue 4 (31 Dec. 2009), pp.54-58, 5 p.
Publisher
University of Baghdad College of Dentistry
Publication Date
2009-12-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : squamous cell carcinoma is a malignant neoplasm of stratified squamous epithelium ; it occurs in different sites and has potential destructive growth and invasive with distant metastasis.
The aims of the study were to evaluate the expression of matrix metalloproteinase-9 and Vimentin immunohistochemistry and to correlate them with the clinic pathological parameters in oral squamous cell carcinoma.
Materials and methods: twenty prospective and eleven retrospective paraffin- embedded formalin- fixed blocks of oral squamous cell carcinoma were included in this study.
Haematoxylin & Eosin stain (H and E) and immunohistochemical staining was done by using monoclonal antibodies for anti-matrix metalloproteinase and anti- Vimentin.
Results: positive immunohistochemical staining for MMP-9 was seen in 100 % of collective cases while it was seen in 93.5 % for Vimentin.
Conclusions : there was no correlation found between the two markers.
MMP-9 expression was found in all cases with no correlation with clinic pathological parameters so it can be used as a diagnostic tumor marker rather than a prognostic marker.
Vimentin was expressed in most OSCC cases with significant correlation with tumor size and stage.
Vimentin can be used as a good prognostic tumor marker.
American Psychological Association (APA)
Khalil, Afrah A.& Majid, Ahlam H.. 2009. Immunohistochemical expressions of matrix metalloproteinase-9 and vimentin in oral squamous cell carcinoma. Journal of Baghdad College of Dentistry،Vol. 21, no. 4, pp.54-58.
https://search.emarefa.net/detail/BIM-288278
Modern Language Association (MLA)
Khalil, Afrah A.& Majid, Ahlam H.. Immunohistochemical expressions of matrix metalloproteinase-9 and vimentin in oral squamous cell carcinoma. Journal of Baghdad College of Dentistry Vol. 21, no. 4 (2009), pp.54-58.
https://search.emarefa.net/detail/BIM-288278
American Medical Association (AMA)
Khalil, Afrah A.& Majid, Ahlam H.. Immunohistochemical expressions of matrix metalloproteinase-9 and vimentin in oral squamous cell carcinoma. Journal of Baghdad College of Dentistry. 2009. Vol. 21, no. 4, pp.54-58.
https://search.emarefa.net/detail/BIM-288278
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 58
Record ID
BIM-288278