Nucleolar organizer regions in giant cell lesions of the jaws in relation to clinico-pathological parameters

Abstract EN

Background: It is to clarify the proliferatiove activity of the multinucleated giant cells and cellular component in giant cell lesions of the jaw in correlation to their clinico-pathological features.

Materials and methods: This study was carried on 23 cases diagnosed as GC lesion of the jaw.

Patient's personal and clinical information were collected from their files.

H and E and sliver nitrate stains were applied on their formalin fixed paraffin embedded tissue sections.

Results: the mean AgNOR count in MGC / cell was 49.83 and NORs / nucleus was 5.8, and 74 % of them were grouped in large clusters and 26 % were scattered.

In PGCG the mean AgNOR count / MGC and /nucleus were significantly lower than that of CGCL (38.2 vs 59.5 and 4.6 vs 6.8 respectively, P < 0.04).

The mean AgNOR count of spindle and mononuclear cells were 4.7 in CGC lesions and 2.5 in peripheral lesions Conclusion : evaluation of AgNORs showed that both MGC and fraction of mononuclear cells in CGCG were significantly higher than that in PGCG.