Low and high density lipoproteins in serum and saliva of ischemic heart disease patients

Abstract EN

Background : Coronary artery disease is one of the main reasons of early death in humans; the initiation of the atherosclerotic plaque is ascribed to focal accumulation of lipids.

Saliva provides an inexpensive, non invasive and accessible diagnostic element.

The aim of this study was to assess Low and high density lipoproteins cholesterol in ischemic heart diseased patients and to assess the role of saliva as a diagnostic tool for this biochemical analysis.

Materials and Methods : Eighty subjects were enrolled in this study, forty patients were diagnosed as ischemic heart disease (IHD), their ages ranged between 42-80 years, and forty individuals were age and sex matched healthy looking volunteers.

Lipid profile has been estimated for all the serum and salivary samples.

Results : the mean level of serum total cholesterol (TC) in healthy controls was higher than that of IHD patients, but it fail to reach a significant level.

The mean levels of salivary TC in healthy controls were significantly higher than that of IHD patients.

The mean levels of serum and salivary HDL in healthy controls were significantly higher than that of IHD group.

There were no significant differences between serum and salivary LDL of IHD patients compared to healthy controls.

The levels of TC, HDL, and LDL are more significant in saliva than in serum in IHD patients compared to healthy controls.

Conclusions : Ischemic heart disease is associated with significant decrease in serum and salivary HDL and non significant decrease in serum and salivary LDL.

Saliva is more significant than serum in this biochemical analysis.