Evaluation of salivary immunoglobulin a and interleukins IL-1 alpha and IL-8 in psoriatic patients with and without geographical tongue

Abstract EN

Background Psoriasis is a common chronic inflammatory skin disorder presenting in various clinical types.

Oral lesions in psoriasis patients are rare and have been clinically presented described as white plaques, erythematous patches, or ulcerations.

An increased prevalence of erythema migrans has been reported.

Aims of the study This study was designed to evaluate the relationship between psoriasis and geographical tongue and determine the salivary secretory immunoglobulin A (S-IgA), IL1α and IL8 in psoriasis patients, as well.

Materials and methods Clinical oral examinations had been done for fifty patients with psoriasis as well as fifty, age and gender, matched control subjects for detecting the presence of geographical tongue and report any oral mucosal changes.

Samples of whole unstimulated mixed (resting) saliva were collected from all participants then investigated for the level of SIgA, IL-1α and IL-8 by Enzyme Linked Immunosorbent Assay (ELISA).

Results : The incidence of geographical tongue was higher among psoriasis patients (20%), in comparison to control group which was (4%).The mean value of salivary IgA was reduced in psoriasis patients, with and without geographical tongue cases.

But the reverse result appeared with IL1α and IL8.

This picture reflects a clear immunological background for geographical tongue that goes at the same direction of psoriatic immunopathology.

Conclusion : Geographical tongue could be an oral manifestation of generalized pustular psoriasis.

Psoriasis patients showed significantly lower concentrations of salivary IgA compared to control.