Aurora B kinase expression in oral squamous cell carcinoma

Abstract EN

Background : The present study was conducted on oral squamous cell carcinoma(OSCC) which is the most common oral malignancies with main objective of showing the expression of Aurora B in OSCC and its correlation to clinicopathological parameters.

Materials and Methods : This study comprised a total of (65) patients diagnosed as OSCC,(48) males and (17) females.

The cases include: well differentiated SCC.

(32) cases, moderately differentiated SCC.(25) and poorly differentiated SCC.

(8) cases.

The expression of Aurora B protein was carried out on 4μm tumor sections using Immuno histochemical staining of Aurora B antibody.

Results : Results showed high expression of Aurora B in the most cases of OSCC with a mean expression about (48.66), in addition to that results showed that the expression of Aurora B was increased with the progression of histological grade and stage of tumor.

Conclusion : Aurora B over expression and its correlation with progression of tumor stage and grade may indicate the association of Aurora B expression with the aggressiveness of tumor.