Relationship between herpes simplex virus type-1 and periodontitis

Abstract EN

Background : HSV-1 is responsible for the most commonly occurring viral infections of the mouth and perioral soft tissues, HSV-1which primarily is associated with oral and labial lesions, and it causes a recurrent infection, which commonly occurs in the mouth.

Additionally, HSV infection has been associated with periodontitis.

The HSV-1 may cause periodontal pathosis as a direct result of virus infection and replication, or as a consequence of virally induced impairment of the periodontal immune defense, resulting in heightened virulence of resident bacterial pathogens.

The aims of the study are to show the relationship between HSV-1 and periodontitis, and to determine HSV-1 Antigen in saliva of periodontitis patients by immunoflourescent, as well as to determine HSV-1 antibodies immunoglobulin G (IgG) in saliva samples by enzyme linked immunosorbent assay (ELISA) test.

Materials and methods : Thirty periodontitis patients and thirty periodontitis patients and have recurrent herpes labials (RHL) compare with thirty healthy control subjects were included in this study.

Saliva samples were taken from all subjects (patients and healthy) and examined by direct immunoflourescent and ELISA test.

Two swabs from patients with oral herpes labials were considered as a positive control.

Results : The present study indicated that there is relationship between HSV-1 and periodontitis and the herpes simplex virus type-1 was detected in periodontitis patients by ELISA and immunoflourescent method.

Conclusion : The study revealed positive association between HSV-1 and periodontitis and the virus may play a role in the pathogenesis of the periodontitis.