Comparison of amelogenin sub-proteins osteoinductive : histopathological study

Abstract EN

-Background: Enamel matrix proteins (EMP) represent one of the most effective members of the bone morphogenic protein (BMP) family.

Materials and methods: Chemical isolation of AM followed by isolation of AM sub-proteins was done using gel filtration chromatography and polyacrylamide gel.

Beside that the histopathological pictures after the application of each AM sub-proteins in a bony defect created in the mandible of hamsters were observed.

Results: Only the intermediate molecular weight sub-protein (application showed a rapid healing process and new bone formation.

Conclusions: Among the 3 AM sub-protein only the intermediate one represents the bone morphogenic factor.

Key words: Enamel matrix proteins, AM sub-proteins.

(J Bagh Coll Dentistry 2008; 20(1)24-27)