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In vitro MIC of itraconazole against different isolates of candida albicans
Other Title(s)
التركيز التثبيطي الأدنى (MIC) لمادة إتراكونازول ( itraconazole) لمجموعات معزولة من المبيضةة البيضاء(candida albicans) في المختبر
Author
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 20, Issue 1 (30 Jun. 2011), pp.33-37, 5 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2011-06-30
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract AR
دواء الاتراكنازول من الأدوية واسعة الطيف المضادة للفطريات.
تم فحص حساسية 38 عزلة من فطر المبيضات Candida albicans (8 عزلات من الأظافر، 10 من التجويف الفموي، 5 من المهبل، 5 من الجروح) لهذا الدواء خارج الجسم بواسطة المثبط الأدنى للنمو (MIC) و بطريقة التخفيف في الوسط السائل حسب (NCCLS).
لم تظهر العزلات مقاومة لدواء الاتراكنازول.
تراوح المثبط الأدنى للنمو من 6.4-0.05 مايكرو كرام / مل، MIC50 يساوي 0.2 مايكروكرام / مل، MIC90 يساوي 1.6 مايكروكرام / مل و عمل الدواء كمثبط للنمو في 25 عزلة و قاتل للفطر في 13 عزلة.
Abstract EN
In vitro antifungal susceptibility test of itraconazole was carried out against 38 isolates from nails, skin, oral cavity, vagina and wounds, This study was done in Ramadi Teaching Hospital in period from January to August 2010.
According to the National Committee for Clinical Laboratory Standard (NCCLS) M 27- A by using the broth dilution method.
Inoculum size was 1-5 X 103 CFU / ml, while final concentrations of itraconazole ranged from 0.025 – 6.4 μg / ml by using RPMI – 1640 broth media and the fungus was incubated at 35 °C.
No resistant stain was recorded.
MIC ranged from 0.05 –6.4 μg / ml and the Mean ± SEM was 0.89 ± 0.28.
MIC for nail isolates was 0.05 – 6.4 μg / ml, for skin isolates it was 0.05 – 6.4 μg / ml, for oral cavity isolates it was 0.05 – 0.4 μg / ml, for vagina isolates it was 0.1 – 6.4 μg / ml and for wound isolates it was 0.1 – 1.6 μg / ml.
MIC50 was 0.2 μg / ml and MIC90 was 1.6μg / ml.
Itraconazole acts as fungistatic more than fungicidal agent ; in 25(65.8 %) isolates it acts as fungistatic and as fungicidal in 13 (34.2 % ) isolates.
American Psychological Association (APA)
al-Shammari, Inssaf I.. 2011. In vitro MIC of itraconazole against different isolates of candida albicans. Iraqi Journal of Pharmaceutical Sciences،Vol. 20, no. 1, pp.33-37.
https://search.emarefa.net/detail/BIM-288746
Modern Language Association (MLA)
al-Shammari, Inssaf I.. In vitro MIC of itraconazole against different isolates of candida albicans. Iraqi Journal of Pharmaceutical Sciences Vol. 20, no. 1 (Jun. 2011), pp.33-37.
https://search.emarefa.net/detail/BIM-288746
American Medical Association (AMA)
al-Shammari, Inssaf I.. In vitro MIC of itraconazole against different isolates of candida albicans. Iraqi Journal of Pharmaceutical Sciences. 2011. Vol. 20, no. 1, pp.33-37.
https://search.emarefa.net/detail/BIM-288746
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 36-37
Record ID
BIM-288746