The expression of epstein-barr virus in breast cancer in relation to age

Abstract EN

-Background: Breast cancer is the most common malignancy affecting females worldwide.

The association of Epstein-Barr virus (EBV) with this cancer is a longstanding interest to this field.

Aim : to investigate the presence of EBV in breast tumor tissue in relation to age.

Patients and Methods : Paraffin-embedded tissue blocks from 45 female patients with breast tumors (ranged in age from 28 to 85 years) were retrieved.

The cases were grouped into two categories : group (A) : included 30 cases with breast carcinoma and group (B) : included 15 cases with benign breast diseases as a control group .The expression of EBV protein was examined Immunohistochemically.

Results : Twelve (40 %) of the 30 breast cancer cases (group A) were reported as positive for EBV expression and significantly higher in patients less than 40 years age (P= 0.026) Conclusion : the results of the current study might refer to the significance of EBV expression in breast tissue of young patients with breast cancer.