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The prevalence and clinical significance of perinuclear antineutrophil cytoplasmic antibody in patients with indeterminate colitis
Joint Authors
Hasan, Raid Muhammad
Mahdi, Batul Matar
Makki, Basimah
Hazim, Wafa
al-Galabi, Lin Khalog
Ghanim, Nahlah
Source
al-Kindy College Medical Journal
Issue
Vol. 7, Issue 1 (30 Jun. 2011), pp.85-88, 4 p.
Publisher
University of Baghdad al-Kindi College of Medicine
Publication Date
2011-06-30
Country of Publication
Iraq
No. of Pages
4
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Background: Indeterminate colitis (IC), a term originated by pathologists to characterize confounding histopathology appearance of resected mucosa, has become catch phrase for cases in which diagnostic criteria at all levels elude classification as Crohn's disease (CD) or ulcerative colitis (UC).
OBJECTIVES: evaluate the prevalence of pANCA expression in the sera and its isotypes.
Patients and methods: PATIENTS GROUP consisted of 60 patients (40 males and 20 females) with indeterminate colitis and their age rangewas (19-84 years).
CONTROL GROUP consisted of 30 (15 males and 15 females) healthy volunteers and their age range were (20- 66 years).
Antineutrophil cytoplasmic ( pANCA and cANCA) testing was performed by an IIF technique on ethanol fixed human EOH granulocytes as substrate (EUROIMMUNE- Germany).
Sigmoidoscope and colonoscope examination were done for the patients group and biopsies were taken from the patients for histopathologically examination.
Results : Serological results of ANCA showed a significant increased frequency of pANCA (63.3 %) in indeterminate colitis patients as compared to controls (p = 0.000).
The highest percentage of this pANCA titer was 1:10 (p=0.000) then 1:100 (p = 0.008) and most of them was IgG (53.3 %) (p = 0.000).
Sensitivity of pANCA was 60 %, specificity of pANCA was 40 %, positive predictive value of pANCA was 61.1% and negative predictive value of pANCA was 66.6 %.
cANCA did not demonstrated in both groups.
Conclusions : pANCA was more prevalent in indeterminate colitis and could be used as a predictive serological marker for the outcome of disease.
American Psychological Association (APA)
Mahdi, Batul Matar& Hasan, Raid Muhammad& Makki, Basimah& Hazim, Wafa& Ghanim, Nahlah& al-Galabi, Lin Khalog. 2011. The prevalence and clinical significance of perinuclear antineutrophil cytoplasmic antibody in patients with indeterminate colitis. al-Kindy College Medical Journal،Vol. 7, no. 1, pp.85-88.
https://search.emarefa.net/detail/BIM-289038
Modern Language Association (MLA)
Mahdi, Batul Matar…[et al.]. The prevalence and clinical significance of perinuclear antineutrophil cytoplasmic antibody in patients with indeterminate colitis. al-Kindy College Medical Journal Vol. 7, no. 1 (Jun. 2011), pp.85-88.
https://search.emarefa.net/detail/BIM-289038
American Medical Association (AMA)
Mahdi, Batul Matar& Hasan, Raid Muhammad& Makki, Basimah& Hazim, Wafa& Ghanim, Nahlah& al-Galabi, Lin Khalog. The prevalence and clinical significance of perinuclear antineutrophil cytoplasmic antibody in patients with indeterminate colitis. al-Kindy College Medical Journal. 2011. Vol. 7, no. 1, pp.85-88.
https://search.emarefa.net/detail/BIM-289038
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 88
Record ID
BIM-289038