Comparison of conventional periodontal therapy versus scaling and root planing with subgingival minocycline gel 2%

Abstract EN

Background : Alternative regimens using sub gingival minocycline plus scaling and root planning (SRP / M) significantly improved clinical attachment (CAL) and reduced probing depth (PD) compared with SRP alone.

The purpose of this study was to evaluate clinical and radiographic outcomes in 2 periodontitis cohorts, one receiving conventional periodontal therapy and the other receiving scaling and root planning with multiple doses of sub gingival minocycline.

Materials and Method : Moderate to advanced chronic periodontitis patients were concurrently treated with either : (1) scaling and root planning with 4 sub gingival doses of minocycline in all ≥ 5mm pockets over a 6 month period (SRP / M) n = 25 patients or (2) conventional therapy 6 month period (SRP n = 25 patients).

Clinical and radiographic measurements including (PD), CAL, BOP and interproximal bone height (BH), were analyzed at baseline and 1 year.

Results : Baseline clinical and radiographic data were similar between SRP / M and SRP patients.

PD showed greater mean improvement in SRP / M (1.1 ± 0.1 versus 0.5 ± 0.1 mm P=0.02) with 25 % of subject of SRP / M gaining ≥ 2mm compared to 4.2 % in SRP.

The mean loss in bone height and percent subjects losing bone height were less in SRP / M (2.9 ± 0.6 mm) than SRP (3.7 ± 0.7mm) while cross sectional SRP / M data between CAL and BH or PD and CAL were highly correlated, changes over 1 year were not correlated among any of these parameters.

Conclusion : Scaling and root planning and sub gingival minocycline in experimental sites resulted in more PD reduction and less frequent bone height loss than conventional periodontal treatment alone.