Metabolic disturbance in diabetic patients with and without urinary ketone bodies

Abstract EN

Objective: Although many biochemical parameters are now available, investigations of diabetic patients with pancreatic disease, yet any one of them alone was found unsatisfactory.

The purpose of this paper is to determine if the pancreatic or liver and kidney function tests are changed in diabetic patients with or without ketosis and whether ketosis show any evidence of pancreatitis in juvenile or adult diabetic patients.

For this reason three groups of diabetic patients associated with either ketotic or non ketotic condition were selected and investigated.

Materials and Methods: The present study deals with investigations on liver and pancreatic function tests in sixty diabetic patients for serum aspartate, alanine aminotransferase, alkaline phosphatase, total lipase and amylase enzymes.

Kidney function tests were also assessed for blood urea and serum creatinine.

Serum total protein and protein fractions were also studied.

In addition, correlation of such finding with age, sex, ketotic state and diabetics (type I & type II) have been investigated.

Results: Although the serum pancreatic enzymes showed normal level in ketotic cases with IDDM, they significantly increased with the degree of diabetic disequilibrium in ketotic cases with NIDDM and in cases with juvenile diabetic ketosis.

In adult cases with either IDDM or NIDDM, the pancreas is properly functioning through treatment with insulin or the pancreas still secretes minimal concentrations of insulin required for diminished lipolysis.

Conclusion: From our data we conclude that the increased lipase and amylase activities are good indicators for the diagnosis of pancreatic tissue injury (pancreatitis) particularly in Juvenile diabetic patients associated with ketosis as compared to diabetic patients without ketosis.