Development of adsorptive stripping voltammetric procedure for the determination of josamycin, a macrolide antibiotic
Joint Authors
al-Ghamidi, Ahmad H.
al-Warthan, Abd al-Rahman A.
al-Shadokhy, Muhammad A.
Source
Issue
Vol. 1, Issue 2 (31 Dec. 2006), pp.171-182, 12 p.
Publisher
Yarmouk University Deanship of Research and Graduate Studies
Publication Date
2006-12-31
Country of Publication
Jordan
No. of Pages
12
Main Subjects
Topics
Abstract EN
A sensitive and simple analytical method is described for the electrochemical behaviour and quantitative determination of Josamycin antibiotic drug in its dosage forms and body fluids.
The developed AdSV method was based on the adsorptive accumulation of the drug at a hanging mercury drop electrode, followed by the electrochemical reduction process, which yielded a well-defined cathodic peak at - 1.38 V (vs.
Ag / AgCl electrode).
This electroanalytical response was further optimised with respect to various experimental and operational parameters.
A linear calibration graph was obtained in the range 1.5 × 10-7 - 3.5 × 10-7 moll-1 with a detection limit of 4.3 × 10-8 moll-1 after 120 s accumulation period at 0.0 V.
The reproducibility of the method in terms of RSD % for 10 measurements was 1.8 % with a mean recovery of 100.7 % Possible interferences by other pharmaceutical drugs and surface-active materials were also investigated.
The proposed procedure was successfully applied for the analysis of the studied drug in commercially available dosage form and in spiked human serum and urine.
American Psychological Association (APA)
al-Ghamidi, Ahmad H.& al-Shadokhy, Muhammad A.& al-Warthan, Abd al-Rahman A.. 2006. Development of adsorptive stripping voltammetric procedure for the determination of josamycin, a macrolide antibiotic. Jordan Journal of Chemistry،Vol. 1, no. 2, pp.171-182.
https://search.emarefa.net/detail/BIM-290075
Modern Language Association (MLA)
al-Warthan, Abd al-Rahman A.…[et al.]. Development of adsorptive stripping voltammetric procedure for the determination of josamycin, a macrolide antibiotic. Jordan Journal of Chemistry Vol. 1, no. 2 (Dec. 2006), pp.171-182.
https://search.emarefa.net/detail/BIM-290075
American Medical Association (AMA)
al-Ghamidi, Ahmad H.& al-Shadokhy, Muhammad A.& al-Warthan, Abd al-Rahman A.. Development of adsorptive stripping voltammetric procedure for the determination of josamycin, a macrolide antibiotic. Jordan Journal of Chemistry. 2006. Vol. 1, no. 2, pp.171-182.
https://search.emarefa.net/detail/BIM-290075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 182
Record ID
BIM-290075