Myocardial performance index in pediatric β-thalassemia major
Joint Authors
Abu Zayd, H. M. H.
Rahman, H. M. A.
Abd Allah, B.
Source
Egyptian Pediatric Association Gazette
Issue
Vol. 55, Issue 2 (30 Apr. 2007), pp.12-15, 4 p.
Publisher
Egyptian Pediatric Association
Publication Date
2007-04-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background: Despite advancement in treatment, cardiac dysfunction remains to be the leading cause of death in patients with 0-thalassemia major.
The pathophysiology of cardiac disease in 0 -thalassemia is complex and may be related to many causes.
Aims: Determine the thalassemia-induced changes of myocardial performance index(MPI).
Methods: 27 patients with 0 -thalassemia major as well as 18 normal subjects were included , clinically evaluated and echocardiographically examined using two dimensional (2-D)-, M-mode, color flow mapping and spectral Doppler echo.
MPI was calculated by dividing the sum of isovolumic contraction and relaxation times by the left ventricular ejection time (McMahon et al., 2004 and Spences et alv 2004).
Investigations included serum ferritin and screening for transfusion-induced hepatitis B and C.
Results: MPI was significantly higher in cases versus controls (0.47 + 0.12 vs 0.39 ± 0.07 , p = 0.01) unlike left ventricular ejection fraction & fractional shortening (EF& FS) which were normal in patients vs controls (66.9 + 5.8 and 36.9 ± 4.8 vs 65.7 ± 6.2 and 35.9 + 4.9 %, P > 0.05) .The MPI correlated with the serum ferritin ( r = 0.49, p = 0.01).
Conclusion: Systolic and diastolic myocardial dysfunction are present in patients with p-thalassemia major and this is better detected by calculating the MPI rather than by measuring the traditional indices of LV function Thalassemia -induced myocardial dysfunction correlates positively with serum ferritin.
American Psychological Association (APA)
Abu Zayd, H. M. H.& Rahman, H. M. A.& Abd Allah, B.. 2007. Myocardial performance index in pediatric β-thalassemia major. Egyptian Pediatric Association Gazette،Vol. 55, no. 2, pp.12-15.
https://search.emarefa.net/detail/BIM-290193
Modern Language Association (MLA)
Abu Zayd, H. M. H.…[et al.]. Myocardial performance index in pediatric β-thalassemia major. Egyptian Pediatric Association Gazette Vol. 55, no. 2 (Apr. 2007), pp.12-15.
https://search.emarefa.net/detail/BIM-290193
American Medical Association (AMA)
Abu Zayd, H. M. H.& Rahman, H. M. A.& Abd Allah, B.. Myocardial performance index in pediatric β-thalassemia major. Egyptian Pediatric Association Gazette. 2007. Vol. 55, no. 2, pp.12-15.
https://search.emarefa.net/detail/BIM-290193
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 14-15
Record ID
BIM-290193