Antlnociciptive effect of ginger extract in streptozotocin-induced oiabetic rats

Abstract EN

Hyperalgesia is one of the major symptoms of diabetic neuropathy in diabetic patients.

Streptozotocin (STZ)-induced diabetic rats display exaggerated hyperalgesic behavior in response to noxious stimuli, and the most commonly employed animal model aspect of painful diabetic neuropathy.

This study was designed to evaluate the analgesic effect of oral Ginger extract on formalin-induced nociceptive responses (standard formalin test) in STZ-induced diabetic rats.

For this purpose, STZ-diabetic rats were orally given the aqueous extract of Ginger roots in a dose of 200 mg kg 7day for one month.

The results showed that three was an increase in the pain scores in both phases of the test in the diabetic group.

It was found out that treatment with Ginger extract significantly reduced blood glucose in diabetic rats and Ginger-treated diabetic rats exhibited a lower pain score for both phases of the test as compared to untreated-diabetic ones.

In contrast, sodium salicylate which acts as positive control only reduced pain scores in the second phase.

It could be concluded that oral intake of Ginger extract for one month has a therapeutic potential for treating painful diabetic neuropathy.