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Clinical profile of distal renal tubular acidosis
Joint Authors
Muthukrishnan, Jayaraman
Modi, K. D.
Jha, Ratan
Harikumar, K. V. S.
Shiradhonkar, Shekhar
Kiran, Patro
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 22, Issue 2 (30 Apr. 2011), pp.261-267, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2011-04-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
Determine the clinical profile and progression of renal dysfunction in distal renal tubular acidosis (dRTA), we retrospectively studied 96 consecutive cases of dRTA diagnosed at our center.
Patients with unexplained metabolic bone disease, short stature, hypokalemia, recurrent renal stones, chronic obstructive uropathy or any primary autoimmune condition known to cause dRTA were screened.
Distal RTA was diagnosed on the basis of systemic metabolic acidosis with urine pH > 5.5 and positive urine anion gap.
In those patients who had fasting urine pH > 5.5 with normal baseline systemic pH and bicarbonate levels (incomplete RTA), acid load test with ammonium chloride was done.
A cause of dRTA could be established in 53 (54 %) patients.
Urological defect in children (22 / 44) and autoimmune disease in adults (11 / 52) were the commonest causes.
Hypokalemic paralysis, proximal muscle weakness and voiding difficulty were the common modes of presentation.
Doubling of serum cretonne during the study period was noted in 13 out of 27 patients who had GFR < 60 mL / min at presentation whereas in only one of the 70 with initial GFR > 60 mL / min (P < 0.005).
In conclusion, urological disorders were the commonest cause of dRTA in children while autoimmune disorders were the commonest association in adults.
Worse baseline renal function, longer duration of disease and greater frequency of nephrolithiasis / nephrocalcinosis and urological disorders were noted in those who had worsening of renal dysfunction during the study period.
American Psychological Association (APA)
Jha, Ratan& Muthukrishnan, Jayaraman& Shiradhonkar, Shekhar& Kiran, Patro& Harikumar, K. V. S.& Modi, K. D.. 2011. Clinical profile of distal renal tubular acidosis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 22, no. 2, pp.261-267.
https://search.emarefa.net/detail/BIM-291424
Modern Language Association (MLA)
Jha, Ratan…[et al.]. Clinical profile of distal renal tubular acidosis. Saudi Journal of Kidney Diseases and Transplantation Vol. 22, no. 2 (Apr. 2011), pp.261-267.
https://search.emarefa.net/detail/BIM-291424
American Medical Association (AMA)
Jha, Ratan& Muthukrishnan, Jayaraman& Shiradhonkar, Shekhar& Kiran, Patro& Harikumar, K. V. S.& Modi, K. D.. Clinical profile of distal renal tubular acidosis. Saudi Journal of Kidney Diseases and Transplantation. 2011. Vol. 22, no. 2, pp.261-267.
https://search.emarefa.net/detail/BIM-291424
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 266-267
Record ID
BIM-291424