Evaluation of lipid peroxidation and erythrocyte glutathione peroxidase and superoxide dismutase in hemodialysis patients
Joint Authors
Karajibani, Mansur
Sanadgol, Houshang
Dikshit, Madhurima
Hashimi, Muhammad
Muntazarifar, Farzaneh
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 23, Issue 2 (30 Apr. 2012), pp.274-279, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2012-04-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
- Oxidation
- Oxidative Stress
- Patients
- Enzymes
- Hemodialysis
- Blood cells
- Lipid peroxidation
- Erythrocytes
- Superoxide dismutase
Abstract EN
Oxidative stress often occurs in chronic hemodialysis (HD).
The aim of the present study was to determine plasma malondialdehyde (MDA) level for lipid peroxidation product and erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities as enzymatic antioxidants.
Thirty-one HD patients (aged 50.3 ± 14.9 years) who were dialyzed three times per week and 31 healthy subjects (aged 47.8 ± 13.9 years) were enrolled.
The results showed lower enzymatic antioxidants activity (GPx, SOD) and higher MDA levels in comparison with control subjects.
In addition, SOD and GPx activities significantly decreased and MDA increased after HD.
We also found that there was a significantly negative correlation between SOD and GPx with MDA.
The results suggest that elevated level of plasma MDA and reduced activities of SOD and GPx can be caused oxidative stress, which may play a critical role in HD complications.
American Psychological Association (APA)
Muntazarifar, Farzaneh& Hashimi, Muhammad& Karajibani, Mansur& Sanadgol, Houshang& Dikshit, Madhurima. 2012. Evaluation of lipid peroxidation and erythrocyte glutathione peroxidase and superoxide dismutase in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 23, no. 2, pp.274-279.
https://search.emarefa.net/detail/BIM-292773
Modern Language Association (MLA)
Muntazarifar, Farzaneh…[et al.]. Evaluation of lipid peroxidation and erythrocyte glutathione peroxidase and superoxide dismutase in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation Vol. 23, no. 2 (Apr. 2012), pp.274-279.
https://search.emarefa.net/detail/BIM-292773
American Medical Association (AMA)
Muntazarifar, Farzaneh& Hashimi, Muhammad& Karajibani, Mansur& Sanadgol, Houshang& Dikshit, Madhurima. Evaluation of lipid peroxidation and erythrocyte glutathione peroxidase and superoxide dismutase in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation. 2012. Vol. 23, no. 2, pp.274-279.
https://search.emarefa.net/detail/BIM-292773
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 279
Record ID
BIM-292773