Reliability of fine needle aspiration cytology (FNAC) as a diagnostic tool in cases of cervical lymphadenopathy
Joint Authors
Hafiz, Nisrin H.
Tahoun, Nifin S.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 23, Issue 3 (30 Sep. 2011), pp.105-114, 10 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2011-09-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Topics
Abstract EN
Purpose : the aim of this work is to evaluate the reliability and diagnostic accuracy of fine needle aspiration cytology (FNAC) of cervical lymph nodes with an emphasis on discordant cases between the cytology and the histopathology.
Patients and methods : this retrospective study was conducted on 157 selected patients with cervical lymphadenopathy that had undergone FNAC.
Cervical nodal enlargement was the first clinical manifestation of the patients in all cases.
Hypocelluar slides were excluded from the current study.
The cytopathological diagnoses were compared with the histopathological results of the same excised nodes.
For all discordant cases, special attention was focused on the cytomorphological features.
Diagnostic sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), accuracy, and discordance rate were calculated.
Results : the cytological diagnoses were found to be benign in 48 cases (30.6 %) and malignant in 109 cases (69.4 %).
The overall diagnostic sensitivity, specificity, positive predictive value, and negative predictive value of FNAC of cervical lymph nodes were 90.9 %, 67.2 %, 82.6 %, and 81.3 %, respectively.
The overall diagnostic accuracy was 82.2 % (129 / 157), while the overall discordance rate was 17.8 % (157 / 28).
The diagnostic accuracy of reactive lymphoid hyperplasia, chronic necrotizing lymphadenitis, chronic granulomatous lymphadenitis, metastatic carcinoma, Hodgkin lymphoma, and Non Hodgkin lymphoma was 85 %, 83.3 %, 70 %, 100 %, 77.8 %, and 75 %, respectively.
Conclusion: The overall diagnostic accuracy of FNAC of cervical lymph nodes was 82.2 % while the overall discordance rate was 17.8 %.
The evaluation of FNA in patients with no previously diagnosed malignancy should be interpreted by an experienced cytopathology's in the context of clinical, radiological, and laboratory finding and if any of these findings is suspicious, further investigation is justified to overcome the limitations and pitfalls of the cytomorphological features when applied alone.
American Psychological Association (APA)
Hafiz, Nisrin H.& Tahoun, Nifin S.. 2011. Reliability of fine needle aspiration cytology (FNAC) as a diagnostic tool in cases of cervical lymphadenopathy. Journal of the Egyptian National Cancer Institute،Vol. 23, no. 3, pp.105-114.
https://search.emarefa.net/detail/BIM-292798
Modern Language Association (MLA)
Hafiz, Nisrin H.& Tahoun, Nifin S.. Reliability of fine needle aspiration cytology (FNAC) as a diagnostic tool in cases of cervical lymphadenopathy. Journal of the Egyptian National Cancer Institute Vol. 23, no. 3 (Sep. 2011), pp.105-114.
https://search.emarefa.net/detail/BIM-292798
American Medical Association (AMA)
Hafiz, Nisrin H.& Tahoun, Nifin S.. Reliability of fine needle aspiration cytology (FNAC) as a diagnostic tool in cases of cervical lymphadenopathy. Journal of the Egyptian National Cancer Institute. 2011. Vol. 23, no. 3, pp.105-114.
https://search.emarefa.net/detail/BIM-292798
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 113-114
Record ID
BIM-292798