Clinical features and outcomes of ANCA-associated renal vasculitis
Joint Authors
Dussol, Bertrand
Brunet, Philippe
Burtey, Stephane
Seck, Sidi Muhammad
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 23, Issue 2 (30 Apr. 2012), pp.301-305, 5 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2012-04-30
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
To determine the patterns and outcomes of the pauci-immune vasculitis in th nephrology department at hospital La Conception in Marseille, we conducted a retrospective study including all patients with diagnosis of pauci-immune renal vasculitis between January 1, 2000 and December 31, 2007.
Among 33 cases, 25 were diagnosed as Wegener granulomatosis (WG), seven as microscopic polyangitis (MPA) and one as Churg-Strauss syndrome (SCS).
The median age of the patients was 57.7 years and the sex-ratio (M/F) was 1.6.
The visceral manifestations included kidneys (100 % of patients), lungs (75 %), ENT (52 % of WG), and nervous system (57 % of MPA).
The mean serum cretonne at admission was 3.3 mg / dL.
Renal biopsies revealed a pauci-immune crescentic glomerulonephritis in 96 % of the cases.
Two patients with WG received plasmapheresis and seven patients required emergency hemodialysis.
Induction therapy comprised cyclophosphamide IV and corticosteroids, while maintenance therapy included azathioprine for the majority of patients.
Eighty four percent of the patients experienced complete remission after induction therapy.
During maintenance therapy relapses were more frequent among patients with MPA (28 %) compared to WG cases (12 %).
After 35 months of follow-up, eight patients ended on chronic hemodialysis, and five patients died.
ANCA associated vasculitis are frequent in our patients.
Long-term outcomes are relatively good despite a mortality rate of 15 % and 25% of the patients entering dialysis after three years of follow-up.
American Psychological Association (APA)
Seck, Sidi Muhammad& Dussol, Bertrand& Brunet, Philippe& Burtey, Stephane. 2012. Clinical features and outcomes of ANCA-associated renal vasculitis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 23, no. 2, pp.301-305.
https://search.emarefa.net/detail/BIM-292800
Modern Language Association (MLA)
Seck, Sidi Muhammad…[et al.]. Clinical features and outcomes of ANCA-associated renal vasculitis. Saudi Journal of Kidney Diseases and Transplantation Vol. 23, no. 2 (Apr. 2012), pp.301-305.
https://search.emarefa.net/detail/BIM-292800
American Medical Association (AMA)
Seck, Sidi Muhammad& Dussol, Bertrand& Brunet, Philippe& Burtey, Stephane. Clinical features and outcomes of ANCA-associated renal vasculitis. Saudi Journal of Kidney Diseases and Transplantation. 2012. Vol. 23, no. 2, pp.301-305.
https://search.emarefa.net/detail/BIM-292800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 305
Record ID
BIM-292800