Rituximab in the treatment of refractory lupus nephritis with vasculitis
Joint Authors
Kadikoy, Husayn
Haqqi, Waqar
Ahmad, Salman
Abd al-Latif, Abdul
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 23, Issue 2 (30 Apr. 2012), pp.334-337, 4 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2012-04-30
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
- Blood-vessels
- Kidneys
- Diseases
- Vasculitis
- Therapeutics
- Inflammation
- Kidney failure
- Lupus nephritis
- Rituximab
Abstract EN
Dysfunction of the B lymphocyte, an important component of adaptive immunity, is thought to be important in the pathogenesis of lupus nephritis (LN).
There are several novel strategies emerging including B-cell depletion by the monoclonal antibodies to B-cell markers, rituximab.
We describe an unusual clinical response of a 22-year-old Hispanic woman with class IV LN with vasculitis while on dialysis to cyclophosphamide (CY) and adjunct rituximab.
The patient had a history of class III / V LN and was treated with nine months of CY and maintenance therapy with mycophenolate mofetil (MMF) for three years.
While on MMF, the patient developed class IV LN with vasculitis leading to end-stage renal disease (ESRD).
While the patient was on peritoneal dialysis, the patient was treated with two doses of rituximab and six doses of intravenous CY.
The patient responded to this regimen and recovered kidney function within four months.
The kidney function remained stable nine months after discontinuing peritoneal dialysis.
American Psychological Association (APA)
Kadikoy, Husayn& Haqqi, Waqar& Ahmad, Salman& Abd al-Latif, Abdul. 2012. Rituximab in the treatment of refractory lupus nephritis with vasculitis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 23, no. 2, pp.334-337.
https://search.emarefa.net/detail/BIM-292854
Modern Language Association (MLA)
Kadikoy, Husayn…[et al.]. Rituximab in the treatment of refractory lupus nephritis with vasculitis. Saudi Journal of Kidney Diseases and Transplantation Vol. 23, no. 2 (Apr. 2012), pp.334-337.
https://search.emarefa.net/detail/BIM-292854
American Medical Association (AMA)
Kadikoy, Husayn& Haqqi, Waqar& Ahmad, Salman& Abd al-Latif, Abdul. Rituximab in the treatment of refractory lupus nephritis with vasculitis. Saudi Journal of Kidney Diseases and Transplantation. 2012. Vol. 23, no. 2, pp.334-337.
https://search.emarefa.net/detail/BIM-292854
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 337
Record ID
BIM-292854