Seminoma in androgen insensitivity syndrome : a case report

Abstract EN

Androgen insensitivity Syndrome (AIS) (testicular feminization syndrome) is a rare Xlinked recessive condition.

These patients characteristically have a 46 XY Karyotype and present with a spectrum of phenotypic abnormalities.

AIS may be complete (CAIS), that is phenotypically normal women with adequate breast development normal external genitalia, vagina of variable depth, absent uterus, and coarse or absent pubic hair and axillary hair.

They are male karyotype with negative sex chromatin.

Partial Androgen Insensitivity Syndrome (PAIS), phenotype range from mildly virilized female with external genitalia (clitorimegaly) to mildly undervirilized male external genitalia (hyopspadius or diminished penile size).

The gonad (undescended) testes may be intraabdominal, inguinal or labial.

Malignant transformation of the testis is rare1.

Here we present a case of a young lady with seminoma arising in CAIS