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Spontaneous remission of post-transplant recurrent focal and segmental glomerulosclerosis
Joint Authors
Said, Bassam
Mazlum, Huda
Askar, Munaf
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 22, Issue 6 (31 Dec. 2011), pp.1219-1222, 4 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2011-12-31
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
Abstract EN
A 12-year-old girl with a history of steroid and cyclosporine (CsA) resistant nephrotic syndrome owing to focal and segmental glomerulosclerosis (FSGS) has progressed to end-stage renal disease (ESRD) for which she underwent hemodialysis for 18 months before she successfully received a fully matched kidney transplant from her sister at the age of nine years.
The post transplantation (Tx) period was marked by an early and massive proteinuria indicating recurrent FSGS for which she received 12 sessions of plasmapheresis (PP) ; unfortunately, she did not appear to have any response to the PP therapy ; thereafter, a conservative management comprising essentially enalapril and losartan has been initiated and was also not successful during the first four months, however, a very gradual response has been noticed to occur after five months of conservative therapy and ultimately, the patient attained complete remission after 21 months of treatment.
Amazingly, 15 months after discontinuation of enalapril and losartan, she remained in a complete and sustained remission with a good renal allograft function.
To the best of our knowledge, this is the first case ever reported in the literature of a “spontaneous” remission of post-transplant recurrent FSGS.
American Psychological Association (APA)
Said, Bassam& Mazlum, Huda& Askar, Munaf. 2011. Spontaneous remission of post-transplant recurrent focal and segmental glomerulosclerosis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 22, no. 6, pp.1219-1222.
https://search.emarefa.net/detail/BIM-293540
Modern Language Association (MLA)
Said, Bassam…[et al.]. Spontaneous remission of post-transplant recurrent focal and segmental glomerulosclerosis. Saudi Journal of Kidney Diseases and Transplantation Vol. 22, no. 6 (Dec. 2011), pp.1219-1222.
https://search.emarefa.net/detail/BIM-293540
American Medical Association (AMA)
Said, Bassam& Mazlum, Huda& Askar, Munaf. Spontaneous remission of post-transplant recurrent focal and segmental glomerulosclerosis. Saudi Journal of Kidney Diseases and Transplantation. 2011. Vol. 22, no. 6, pp.1219-1222.
https://search.emarefa.net/detail/BIM-293540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1222
Record ID
BIM-293540