Isolation, complete nmr data and hepatoprotective activity of sweroside as major constituents of centaurium spicatum (L.) Growing in Egypt
Other Title(s)
فصل مركب السويرسايد كمركب أساسي من نبات القنطريون و تقييم فعاليته كمضاد لأمراض الكبد
Author
Shahhat , Abd al-Ati Abd al-Aziz
Source
Journal of the Arab Society for Medical Research
Issue
Vol. 1, Issue 1 (30 Jun. 2006), pp.92-96, 5 p.
Publisher
Arab Society for Medical Research
Publication Date
2006-06-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract AR
مركب السيكواريدويد (سويروسايد) تم فصله من نبات القنطريون كمركب أساسي و تم تعريفه باستخدام جهاز الرنين المغناطيس و جهاز طيف الكتلة و تضمنت الدراسة الأثر البيولوجي للخلاصة الكحولية و مركب السويروسايد على كل من نمو تكاثر الخلايا المنزرعة و مدى حمايتها ضد سمية رابع كلوريد الكربون و حساب المعامل العلاجي المبدئي و كذلك الأثر البيولوجي لعقار السليمارين كعقار مرجعي لعلاج أمراض الكبد.
Abstract EN
OBGECTIVE: The secoirodoid sweroside was isolated as a major compound from Centaurium spicatum and identified by 1H and 13C-NMR and Fab-Mass as well the hepatoprotective activity of the 80% of the total extract and the sweroside compound were evaluated.
METHODS: The isolation and identification of sweroside from Centaurium spicatum was carried out using TLC, Column chromatography, Fab Mass and NMR spectroscopy and the hepatoprotictive activity was carried out according to Kiso et al., 1983.
RESULTS: Isolation and complete NMR of sweroside compound was carried out.
The toxic concentration of 80 % alcoholic extract is more than 1000 ?g/ml.
Whereas, the concentration that kills half of the cultured cells by sweroside was 50 ?g/ml CONCLUSIONS: The sweroside compound was isolated as the major compound from Centaurium spicatum and identified by 1H and 13C-NMR and Fab-Mass.
Eighty percent alcoholic extract of Centaurium spicatum is high safe compound with a potent hepatoprotective
American Psychological Association (APA)
Shahhat , Abd al-Ati Abd al-Aziz. 2006. Isolation, complete nmr data and hepatoprotective activity of sweroside as major constituents of centaurium spicatum (L.) Growing in Egypt. Journal of the Arab Society for Medical Research،Vol. 1, no. 1, pp.92-96.
https://search.emarefa.net/detail/BIM-29363
Modern Language Association (MLA)
Shahhat , Abd al-Ati Abd al-Aziz. Isolation, complete nmr data and hepatoprotective activity of sweroside as major constituents of centaurium spicatum (L.) Growing in Egypt. Journal of the Arab Society for Medical Research Vol. 1, no. 1 (Jun. 2006), pp.92-96.
https://search.emarefa.net/detail/BIM-29363
American Medical Association (AMA)
Shahhat , Abd al-Ati Abd al-Aziz. Isolation, complete nmr data and hepatoprotective activity of sweroside as major constituents of centaurium spicatum (L.) Growing in Egypt. Journal of the Arab Society for Medical Research. 2006. Vol. 1, no. 1, pp.92-96.
https://search.emarefa.net/detail/BIM-29363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 95-96
Record ID
BIM-29363