Turner syndrome : demography, auxology and growth during growth hormone treatment. final and near-final adult height
Joint Authors
Farid, Tariq M.
al-Khuly, Muhammad Salah
Atif, Abir
Badawi, Nurah al-Said
Amin, Maha
Kamil, Abd al-Karim
Kamil, Ashraf F.
Source
Egyptian Journal of Applied Endocrinology
Issue
Vol. 22, Issue 1-2 (31 Jul. 2004), pp.115-127, 13 p.
Publisher
The Egyptian Society of Applied Endocrinology
Publication Date
2004-07-31
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Turner Syndrome (TS) is the most common chromosomal disorder causing short stature in females.
The consequence of childhood growth failure is marked short stature in adulthood: the average height of untreated women with TS is 143cm.
Treatment with human recombinant growth hormone (rhGH) in an attempt to improve height in childhood and adulthood has become a common practice.
We examined the demographic and auxological features of a number of Egyptian school girls with TS and studied the growth-promoting effects of rhGH on their short stature.
Twenty eight scliool children with TS confirmed by chromosomal analysis were examined before and during treatment with rhGH.
Demographic and auxological features, as well as adverse effects of the drug were important considerations.
TJie study period continued for a period of up to four years with three monthly assessments.
Growth hormone deficiency, partial or complete, was found in seven of the patients.
Mean height SDS in the study group improved from -4.4 ± 1.03 SD at start of treatment to -3.2 ± 0.94 SD by the end of the period when compared with normal healthy girls.
Target lieight -Estimated mature lieight dropped from 14.
92cm to 10.
77cm by the end of the third year and this was significant.
Maximum growth Occurred in the first year of treatment (mean growth velocity - 6.2cm) and dropped progressively thereafter.
Height gained during the study period correlated negatively with age at starting treatment but showed no correlation with GH peak levels in patients.
We found that rhGH had a significant growth promoting effect in children with TS with very few side effects.
American Psychological Association (APA)
al-Khuly, Muhammad Salah& Atif, Abir& Badawi, Nurah al-Said& Amin, Maha& Farid, Tariq M.& Kamil, Abd al-Karim…[et al.]. 2004. Turner syndrome : demography, auxology and growth during growth hormone treatment. final and near-final adult height. Egyptian Journal of Applied Endocrinology،Vol. 22, no. 1-2, pp.115-127.
https://search.emarefa.net/detail/BIM-295103
Modern Language Association (MLA)
al-Khuly, Muhammad Salah…[et al.]. Turner syndrome : demography, auxology and growth during growth hormone treatment. final and near-final adult height. Egyptian Journal of Applied Endocrinology Vol. 22, no. 1-2 (Jul. 2004), pp.115-127.
https://search.emarefa.net/detail/BIM-295103
American Medical Association (AMA)
al-Khuly, Muhammad Salah& Atif, Abir& Badawi, Nurah al-Said& Amin, Maha& Farid, Tariq M.& Kamil, Abd al-Karim…[et al.]. Turner syndrome : demography, auxology and growth during growth hormone treatment. final and near-final adult height. Egyptian Journal of Applied Endocrinology. 2004. Vol. 22, no. 1-2, pp.115-127.
https://search.emarefa.net/detail/BIM-295103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 124-127
Record ID
BIM-295103