Lipoprotein "a" and lipid profile in diabetic patients with and without microalbuminuria

Abstract EN

Background : Lipoprotein (a), a macromolecular complex found in human serum is composed of 2 components.

One of these is apoprotein (a), which differs from other apolipoproteins and has a structural homology with plasminogen of the blood clotting system.

The other component is a low density lipoprotein like particle which contain apo P-100.

Lipoprotein (a) is a quantitative genetic trait which is expressed in wide range of concentrations within a given population.

It exhibits considerable inter and intra, individual density heterogeneity attributed to apo (a) isoforms.

High concentrations of lipoprotLein (a) were reportedly associated with incrased risk of coronary artery disease and cerebral infarcts.

Objective: To study the behaviour of lipoprotein (a) in association with otlier lipid profiles in various diabetic populations and its potential association with some diabetic complications.

Study Design: The study was conducted on 60 subjects; 15 normal healthy subjects and 45 diabetic patients.

All were subjected to full clinical history, examination, routine investigations including (complete urine analysis, fasting blood sugar, serum creatinine) and special investigations including serum lipoprotein (a), lipid profile, HbAlc and detection of microalbuminuria by micral test and exclusion of macroalburnin-uria by Combur test.

The diabetic patients had been categorized into three groups: group 1: 15 type 2 diabetic patients with microalbuminuria group 11: 15 type 1 diabetic patients with microalbuminuria and group 111; 15 diabetic patients without microalbuminuria.

We-found no significant increase of serum Lp (a) in NIDDM, IDDM patients with or without microalburninuria compared to the normal control.

No relation between glycemic control and Lp (a) level.

No significant relation between Lp (a) and other lipid profile.

No relation between Lp (a) level and occurrence of neuropathy or retinopathy.

Conclusion From our study we conclude that: - There is no significant increase of serum Lp (a) in NIDDM, IDDM patients With or without microalburninuria compared to the normal control group.

- There is no relation between glycemic control and Lp (a) level.

- There is no significant relation between Lp (a) and other lipid profile in the studied groups.

- There is no relation between Lp (a) level and occurrence of neuropathy or retinopathy.