Neurocognitive effects of phenobarbital discontinuation in children
Joint Authors
Tonekaboni, S. H.
Beyraghi, N.
Agha, Mohammad Pour M.
Bahreynian, S. A.
Husayn, Zadah Z. T.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 8, Issue 3 (31 Jan. 2006), pp.25-29, 5 p.
Publisher
Publication Date
2006-01-31
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Topics
Abstract EN
Objectives: Phenobarbital (PB) is the most widely used antiepileptic drug in the world, but its possible deleterious cognitive and behavioral side effects remain and important concern among physicians and patients.
We attempt to investigate whether discontinuation of PB in epileptic children was accompanied by improvement in cognitive function.
Design and methods: Evaluation of neuropsychiatric performance was performed by Wechsler intelligence Scale for Children-Revised (WISC-R), in 2 consecutive periods of 7 months interval, in 2 groups of epileptic children between 6-12 years old who were seizure free for at least 2 year and who were taking only PB as antiepileptic drug.
The case group consisted of 24 patients for whom PB was discontinued and the control group consisted of 21 children who continued to take PB.
Results: Results indicated that discontinuation of PB improved total IQ scored compared to control group (p=0.027), and this increase was mostly in performance (nonverbal) items while verbal items remained almost unchanged.
Conclusion: These findings suggest that PB affects cognitive function; and the performance (nonverbal) deficits are reversible after therapy discontinuation.
American Psychological Association (APA)
Tonekaboni, S. H.& Beyraghi, N.& Agha, Mohammad Pour M.& Bahreynian, S. A.& Husayn, Zadah Z. T.. 2006. Neurocognitive effects of phenobarbital discontinuation in children. Iranian Red Crescent Medical Journal،Vol. 8, no. 3, pp.25-29.
https://search.emarefa.net/detail/BIM-29650
Modern Language Association (MLA)
Beyraghi, N.…[et al.]. Neurocognitive effects of phenobarbital discontinuation in children. Iranian Red Crescent Medical Journal Vol.8, No.3, (January, 2006), pp.25-29.
https://search.emarefa.net/detail/BIM-29650
American Medical Association (AMA)
Tonekaboni, S. H.& Beyraghi, N.& Agha, Mohammad Pour M.& Bahreynian, S. A.& Husayn, Zadah Z. T.. Neurocognitive effects of phenobarbital discontinuation in children. Iranian Red Crescent Medical Journal. 2006. Vol. 8, no. 3, pp.25-29.
https://search.emarefa.net/detail/BIM-29650
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 28-29
Record ID
BIM-29650